Sai - Make it better togther

Contact a Representative

Contact us to discuss your requirements

US: Eric Neuffer: +1 908 850 3460
Europe: Dirk Sartor, PhD: +49 152 3361 4996
Asia Pacific: K. Karthik +91 (0)998 930 2255
Global: Marcel Velterop: +41 (0)797 733 453

Email: info@sailife.com

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A selection of relevant technologies beyond the more typical ones routinely applied are listed below:

  • Strong expertise in C-C bond formation utilizing:
  • Organometallic Chemistry-Suzuki, Sonagashira, Kumada, Negishi and Heck coupling reactions – executed on 150-200 Kg scale.
  • Olefin metathesis using second generation Grubbs catalyst – 2 Kg scale
  • Cyclo additions using click chemistry – 50 Kg scale
  • Boronates and Boronic acid synthesis – 60-70 Kg scale
  • Cryo reactions (-78°C) with n-BuLi, LDA and Li-HMDS –200-250 Kg Scale.
  • Hazardous chemistry (Nitration, POCl3 and BBr3 reactions) – 200-250 Kg scale.
  • Hydrogenations at pressures ( upto 10 Kg (150 psi) pressure) – 300 Kg scale.
  • Carbonylation reaction (insertion of CO at 15-20 Kg pressure) – 110 Kg scale.
  • Prostaglandin and Vitamin D Platform
  • Saccharide chemistry for oligo building blocks and Amidites
  • Solution phase peptides up to 10-mer
  • High Potency 1.0-10 µg/m3 (OEL 3) in lab, pilot and commercial plant
  • Experience in handling commercial scale HPLC of Novasep make. Diameter 30 cm and 55 cm long column with a pressure rating of 100 bar with Dynamic Axial Compression packer
  • Preparative scale chromatography and large scale in the Kilolab facility for final purification of API
  • Freeze drying (Lyophilization) capacity of 20 L/day of water evaporation in Kilo-scale
  • Chiral chemistry – Asymmetric synthesis (Evans Aldol, CBS and Noyori reduction) and chemical resolutions – 50-100 Kg
  • Synthesis of oligosaccharides; Nona/hepta/penta saccharides with haptens– 10-20 g scale
  • Reductions using metal hydrides (LAH, Red-Al, Superhydride, LiBH4 etc) – 150-200 Kg
  • Isolation of complex natural products from latex.
  • Synthesis of Complex Molecules – Multistep (up to 34 steps)

Diverse Formulations Technology Selection Helix

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