27 Science-driven pipeline: Glimpses of few projects handled by us in 2020-2021 Flow chemistry to create safer and rapid reaction conditions Flow chemistry plays a key role in drug discovery, chemical process development, and manufacturing in the pharmaceutical industry. With the client tech pack, subject matter experts carried out a flow reaction in optimized process conditions. A detailed process safety study was carried out to know the level of exotherms. The R&D team focused on handling hazardous chemicals in flow, getting it first time right, running of a flow chemistry to meet safety and quality attributes and safe production of material in a continuous chemistry. The desired purity was (~95%) and % of dimer (< 4.0%). Sustainability thinking in action: Greenness Index With the adoption of the greenness index, we are seeking to embrace sustainability outcomes. While greening the process is welcome, the challenges are multifold. Yet, we are encouraged to boldly traverse the spectrum of areas, at laboratory scale, where sustainability can be integrated into route selection, the nature of starting materials, and then translated into the manufacturing process. Thegreenness index, our in-housedevelopedcomputationalmodel, enablesus to lookat these three aspects and many more to build a favorable environmental footprint. The environmental goal is dovetailed with cost-effectiveness, throughput, and scale-up viability--- a dynamic challenge that we address with R&D efforts and process technology. Our strategy of introducing green chemistry at the right time is paying off. We are witnessing a paradigm shift as we baseline customer-designed R&D or manufacturing process and value add with “greenness”, in medium to late-phase projects which comprise 65% of our portfolio. We seek to address potential long-term impacts arising out of a less green process and have formalized green chemistry-based transformation in the technical package. Customer Focus Our Contribution Developing precision-targeted therapeutics to treat patients with complex cancers. 1. Incorporated Tetra Ethylene Glycol chemistry and rapid support for validations by AR&D. Implemented scalable alternative for dry ice; optimized catalyst loading, removed DME (which is an unfavourable solvent due to toxicity). Developed a scalable route for multigram and kg synthesis of lead compound with +99.9% purity and enabled identification of the desired polymorph. Intermediate product involving Suzuki Coupling. 2. Innovative biopharmaceuticals for rare diseases driven by genetic causes. 3.
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