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Medicinal and Synthetic Chemistry

For over 25 years, Sai Life Sciences has been a trusted partner in synthetic and medicinal chemistry. Our expertise spans a wide range of chemotypes and includes some of the most complex chemistries. We invite you to connect with us to explore how our focus on speed and innovation is driving therapeutic discovery across small molecules, peptides, and drug conjugates.

Highlights

  • Over 300 discovery programs across medium & large
    pharma and start-ups
  • 40+ programs advanced to Investigational New Drug
    Application (IND) filing & beyond
  • Robust Intellectual Property (IP) protection
  • Integrated platform for Computational Chemistry,
    Medicinal Chemistry, Biology services with DMPK and
    Toxicology
  • SaiSynth: Integrated project management tool to track
    the flow of compounds and information for efficiently
    managing the DMTA programs
  • Integrated automated compound management for
    sample preparation and compound storage

Experience across wide range of chemistries

  • Asymmetric synthesis Biotinylated/BODIPY/
    Fluorescein labelled compounds
  • Carbohydrates & Azasugars Chiral pool synthesis
  • Drug conjugates for ADCs Heterocycles
  • Isotope labelled (13C & 2D) synthesis Lipids &
    PEG-chemistry
  • Macrocycles
  • Natural products, Nucleosides & Nucleotides Peptides
  • PROTACs
  • Chemical probes Steroids

Key Services

  • Design and synthesis of NCEs to support hit to
    candidate discovery programs
  • Design and synthesis of focused libraries with parallel
    medicinal chemistry
  • Synthesis of reference compounds, metabolites and
    impurity markers
  • Computer-aided drug design (CADD)
  • Peptide Chemistry
  • Scale up and discovery process chemistry
  • TPD libraries and building blocks
  • Analytical and purification services

Infrastructure

  • State of the art chemistry labs with modern equipment
  • Ergonomically designed with efficient workflows
  • In built Lean & 5S approaches
  • Dedicated analytical support for each lab
  • Easy access to related capabilities – HTE, Photoredox,
    Electrochemistry and Flow Chemistry