70 As a CDMO, we handle different kinds of processes involving exothermic reactions, hazardous raw materials and highly hazardous reactions. Therefore, it is important to establish a process safety strategy upfront. To establish the most appropriate basis of safety requires knowing which tests to conduct and how to interpret the obtained data effectively. The expertise of our process safety team is crucial to successful evaluations. We ensure the safe development and scale-up by evaluating the thermal stability of substances, calculating process-related heat production and pressure rates, studying reaction kinetics, and the flammability and dust explosion properties of powders. Thermal stability testing of the materials and mixtures used in the process is completed using instruments such as a Differential scanning Calorimeter (DSC), a Thermal Screening Unit (TSu) and/or Accelerating Rate Calorimeter (ARC). For scale-up decisions, we carry out extensive studies across Simular Reaction Calorimeter (SRC), DSC, TSu, and ARC. As we accord high importance to process safety, we use advanced instruments such as TSu, ARC, which give essential data beyond regular DSC process investigations. These instruments are expensive, yet we make such investment in line with our values and our commitment to our people’s safety and be a reliable partner for our customers. We continuously monitor and evaluate exposure hazards and have advanced containment systems in the laboratories, pilot plants, and manufacturing blocks validated to 1μg/m3. Containment equipment is designed and customized to our needs with the help of reputed global manufacturers through ergo-modeling. Fume cupboards, ventilated enclosures, equipment trains comprising reactors, and filter-dryers are equipped with containment facilities designed to meet stringent requirements and validated. We have a dedicated Industrial hygiene expert in our team who conducts exposure assessments across our facilities and has established in-house competence in personal monitoring of solids, vapours, noise, heat stress, and surrogate validation of containment equipment. We conducted several qualitative and quantitative exposure assessments across R&D and manufacturing sites in the reporting period. More than 130 personal exposure monitoring samples were collected, and our internal experts conducted 10+ containment validations. Industrial Hygiene (IH) SRC 106 ARC 78 Key Features TSu 168 DSC 450 Process Safety Evaluations Comprehensive process safety evaluations to define basis of safe operation
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