37 ....................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Process improvement by using continuous flow and develop/ fit the process to commercial scale to save the high usage of raw material consumption Improved the conversion to 75-80% vs. 38-42% in batch, and selectivity 98% Vs 75% in batch Higher conversion towards the desired isomer Safe operation in closed conditions and increased thermal control Green chemistry is part of the shared focus We seek to make it second nature to develop sustainable processes from the beginning with the early adoption of green chemistry. Solvent selection is a key component in the overall sustainability profile of a manufacturing process. In the pharmaceutical industry, around 50% of materials used to manufacture bulk active pharmaceutical ingredients are solvents. We are currently focused on reducing material intensity by reducing the overall quantity of materials used to create a product including solvents. Embedding Green Chemistry Principles An in-house computational model, the Greenness Index, has been developed to assess projects on water conservation, resource conservation, solvent management, and waste management. This composite metric is computed using several attributes across atom & mass efficiency, e-factor, water conservation, waste minimisation, resource conservation and greenness of solvents. The indicators are tracked and monitored by process development teams and included as part of technical packages. The percentage change in the Greenness Index between pre and post development process is considered as the measure of improvement. Synergizing chemistry and process engineering expertise in flow chemistry As flow chemistry & continuous manufacturing play an increasingly significant role in the small molecule landscape, we engaged in projects both at the laboratory and pilot scale. While we invest in scientific excellence, we tie it together with a ‘Time for Science” program with the teams (PR&D, AR&D, PE and TAT) brainstorming solutions to benchmark and reduce the duration for development, technology transfer and pre-production. 100+ simplification ideas were proposed and 22 ideas towards eliminating non-value-adding activities, automating manual steps and simplifying processes were successfully implemented. Sustainability success in process development In the reporting period, we explored 720 reactions across 16 different projects in flow chemistry.
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