32 Automation in DMPK services • We invested in the infrastructure and automated (liquid handlers) technology for the development of high through ADME screens to support clients • To boost automation, we installed IDOT liquid handler, Biomek i7, dual integrated hybrid liquid handler, API7500 and Thermo Orbitrap Exploris240 to accelerate speed of ADME screens and support large volumes of ADME screens • We further augmented our specialization of developing customized ADME screens to solve the complex problems of the customers associated with the discovery and development programs High-Potency API Manufacturing facility at Bidar Chemistry, Manufacturing and Controls (CMC) Our CMC vertical offers customers comprehensive capabilities from process development through to scale-up and early phase supplies. Over the last two decades, the company has consistently delivered on a diverse set of NCE development programs for its customers with a track record of bringing value based on quality, pricing and responsiveness. Manufacturing As part of being a sustainable partner, we added a new High Potency API (HPAPI) manufacturing facility at our cGMP API Manufacturing campus in Bidar, India. The addition of this new facility expanded our expertise across HPAPI development and manufacturing, providing our customers with a streamlined pathway for NCE development. In 2022, we opened the HPAPI development facility at the R&D campus in Hyderabad. Now, with the addition of the new HPAPI production facility in Bidar, the company is capable of handling of all aspects of the project life cycle spanning process development, analytical development, particle engineering, warehousing, pilot, scale up, sampling, QC, powder processing, effluent treatment, packing, transportation and stability services. The new 16000 sq. ft. HPAPI block, located in the Bidar Manufacturing unit has the following features: • Designed and validated to handle high potent molecules less than 1 μg/m3 containment • Inbuilt warehouse to store KSMs, intermediates and finished goods • Dedicated sampling / dispensing area with isolators with three independent streams to handle commercial scale batches • Reactors to handle multiple unit operations equipped with isolators and split butterfly valves (SBVs) • Powder processing and packing area with isolators; dedicated isolator train for Quality Control testing • Deactivation facility Viaflow 384 Genevac EZ – Solvent Evaporator Biomek i7 Hybrid Dual Integrated – Liquid Handling System I-DOT – Liquid Handling System
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