Stay up to date with our newsletter

Get in touch!

To explore career opportunities with Sai Life Sciences, share your CV here.

Lets start the conversation!

Sign up to our newsletter

Thank you!
We will be in touch shortly.

Delivering pharmaceutical elegance and physiochemical stability with lyophilisation

Complex small molecule APIs present unique formulation and stability challenges. Lyophilisation or freeze drying, a 3-stage interconnected process involving freezing, sublimation and desorption, helps deliver these agents in a form that can be easily reconstituted and administered to the patient.
Sai Life Sciences has extensive experience in the development and optimisation of the lyophilisation process and ensures smooth scale-up of the product with the help of best- in-class equipment operated by highly trained personnel.

Delivering pharmaceutical elegance and physiochemical stability with lyophilisation
Best-in-class infrastructure


  • Successfully deployed lyophilisation in several critical projects
  • Lyophilisation cycle development to help freeze dry heat-sensitive drugs to improve stability and enhance shelf life
  • Developed customised freeze-drying programmes (or recipes) to match desired product specifications
  • Digitally controlled system that ensures alignment with the defined lyophilisation process
  • Prioritised safety by minimising exposure to the lyophilised substance with closed trays (covered by expanded PTFE on polypropylene)
  • Optimised process parameters effectively in pilot studies enabling smooth scale-up

Best-in-class infrastructure

  • Pilot scale
    – 30L capacity, MOC: SS316L
    – Condenser temperature: -85°C
    – Shelf temperature: -65 to +65°C
    – Maximum vacuum: 10 millitorr
  • Scale-up lyophilisers
    – 18L and 300L capacity
    – Located in class 100,000 clean rooms
    – Maximum loading volume of 2L per tray for both units
    – Freeze drying range -50° to 70°C