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Your trustworthy partner enabling drug discovery success

Fast-track your drug discovery with our Drug Metabolism and Pharmacokinetics (DMPK) services – where speed meets precision. Our rapid, quality, and customized solutions are the keys to unlocking success in drug discovery and innovation. Choose efficiency, choose excellence – choose DMPK at Sai to bring Medicines to Life. Fast.

Our Promise

  • Prompt service
    – ADME Tier 1 screening results in 3-5 days
    – PK results within 5 days after compound receipt
  • Customizable study designs
  • Dedicated DMPK leads
  • Swift and accurate scientific inputs
  • Professional and customized reports
  • Competitive pricing & flexible business models

In Vitro ADME

In vitro ADME services – where precision meets efficiency. Our centralized lab ensures accuracy and efficiency, while our dedicated cell culture suits cultivates success. Automation at our core minimizes errors, ensuring reliable and efficient results at higher throughputs and faster turnaround time.


Our Services

  • Physicochemical properties / Stability studies
  • Permeability / Absorption
  • Pgp substrate study (Caco2 / MDCK-MDR)
  • Metabolism (liver microsomes, hepatocytes, S9, etc.)
  • Metabolic stability / intrinsic clearance / Glucuronide conjugation
  • Transporters
  • Drug-Drug interaction (DDI)
  • Time dependent inhibition (TDI)
  • CYP induction
  • CYP phenotyping
  • Plasma and tissue protein binding
  • Blood-to-plasma ratio (RBC partitioning)
  • Metabolite identification / biotransformation /reactive metabolite
  • HERG Patch clamp


  • Automated workstation Biomek-i7 (Beckman Coulter)
  • I DOT Deep Well (Dispendix)
  • ALPS5000 (Thermoscientific)
  • Viaflow384 (Integra)
  • SPGenevac EZ-2 4.0 (ATS)
  • Optima Max- XP Ultracentrifuge (Beckman Coulter)
  • Spectramax iD5 (Molecular Devices)


Customer Testimonial

“Sai’s DMPK team is an outstanding partner in early and late stage optimization. I would highly recommend considering them if you are looking for a highly talented team of scientists in for this aspect of your research. It has been exciting to see the continued investment Sai is making, not only in their facilities but in their talented teams.”

– Frank Hollinger, VP Cheminformatics at Vibliome Therapeutics, LLC

In Vivo PK

In vivo Pharmacokinetics Services – where timely data delivery, analyses, right interpretations and correlations with in vitro data drives drug discovery forward towards right candidate selection. Our expanded facilities feature dedicated spaces for animal holding, procedures, and surgical rooms to support rodent PK studies. From formulation screening to mass balance/tissue distribution studies, we offer a comprehensive solution, navigating the intricate pathways of in vivo drug metabolism, absorption, distribution, and excretion with expertise and precision.


Our Services

  • Bioavailability and pharmacokinetics studies in mice, rats and dogs
  • Neuro PK (plasma, brain and CSF) in mice and rats
  • Ocular PK (Ocular tissues like aqueous humor, vitreous humor, sclera, conjunctiva, lens, cornea, iris, optic nerve and choroid retina)
  • Single, multiple and cassette dosing of compound(s)
  • Entero-hepatic recirculation in Bile-Duct-Cannulated rats
  • Metabolite characterization and identification
  • Dose escalation (dose linearity and range finding)
  • Tissue distribution (brain, heart, liver, lung, kidney, etc.)
  • Site specific absorption studies via intra-duodenal, intra-portal, etc.
  • Delivery through constant infusion i.e. Alzet® osmotic pumps
  • Oral solid-state PK characterization using rodent Capsules (Tropac®)
  • Toxicokinetics analysis and data interpretation


  • Waters® UPLC-MS\MS-API 4000 (AB Sciex)-Triple
  • Quadra Mass Spectrometer
  • Waters® UPLC-MS\MS-API 4000 Q-TRAP (AB Sciex)-Mass Spectrometer
  • HPLC (LC20A System) with UV detector (Shimadzu)
  • Waters® UPLC
  • Deep Freezers (-80°C)
  • Polytron Homogenizer PT MR3100D
  • QIAGEN TissueLyser


Bioanalytical Services

Dive into the forefront of DMPK with Sai’s Bioanalytical services. Our advanced approach guarantees precision in analyzing drug concentration and behavior. Rely on our expertise to elevate the accuracy and efficiency of your DMPK studies, unravelling the complexities of drug development with clarity.


  • SCIEX Triple Quad™ 7500 LC-MS/MS System
  • Orbitrap Exploris™ 240 Mass Spectrometer
    • Quantitative precision and accuracy; can resolve more target ions from matrix interferences
    • Intact mass analysis up to 8000 Da for peptides
    • Inbuilt specific scan mode to support oligonucleotides
    • Detection of lower (<100 m/z) molecular weight biomarkers
    • Intelligent & automated data acquisition using AcquireX intelligent data acquisition workflow
  • Aquity UPLC (Waters)
  • Automated workstation Biomek-i7

Ion-Channel Physiology & Safety Pharmacology

Step into the frontier of ion-channel physiology and safety pharmacology at our state-of-the-art facility. Anchored by a dedicated lab specializing in manual patch-clamp setups, we empower precise cardiotoxicity profiling and drive pioneering research in ion-channel dynamics. Experience the excellence in the ion channels research where innovation and safety converge, unlocking insights crucial for advancing pharmaceutical science.

Compound Management

Optimize your DMPK processes with our comprehensive compound management solutions. Our tailored approach ensures the efficient handling, storage, and distribution of compounds, streamlining workflows for enhanced precision and reliability in your research.

Our Services

  • Dispensing of Solid Compounds in Daughter Vials
  • Dissolution of Compounds to Form DMSO Stock
  • Creation of assay ready plates


  • Tecan Fluent 780
  • Mosaic SampleBank software


  • AAALAC and OLAW accredited animal care program, registered with CPCSEA for breeding
  • Adherence to national and international standards with experienced veterinary staff
  • Separate rooms for quarantine, housing, surgery, experimentation and necropsy
  • Automated data logging system for monitoring environmental conditions and light cycle
  • Conventional as well as individually ventilated cage (IVC) housing for immuno-compromised studies
  • Dedicated scientific/technical staff for key areas

“The focus of innovator companies on diversifying their supply chains bodes well for Indian CROs-CDMOs like ours. This expansion of our DMPK capabilities demonstrates our commitment and appetite for large, complex programs and our readiness to offer world-class DMPK services at scale.”

– Krishna Kanumuri, CEO & Managing Director

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