Blog
2023.04.03
Innovative use of Spherical Agglomeration at scale to manufacture API with improved ‘flow’ property
Solving tough scientific challenges is our raison d’etre. This often leads us along under-explored paths that are both challenging and exciting. One of the sophisticated particle design techniques that is used to improve an API particle’s ‘flow property’, among other physical properties, is Spherical Agglomeration. This technique is considered to be a complex one – […]
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2022.06.07
How PAT tools can help improve understanding of the crystallisation process
The criticality of Crystallisation process in the manufacture of drug substancesThe importance of crystallisation in the pharmaceutical and high-value chemical industries has increased recently due to many technical and commercial factors in last decade: These demands denote the process development is now more focused than ever before, in developing better crystallisation processes for intermediates (where […]
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2022.04.11
CDMO Conferences in 2022
Outsourcing of R&D and Manufacturing has seen over a 50% budget increase in 2021, according to a report by CPhI, the record number of investments in discovery pipelines coupled with broader macro factors is going to drive huge growth for CDMOs in the next 2-3 years. Full-service CDMOs, both large and medium scale, are looking […]
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2022.03.01
Trends in High Throughput Screening
What is High Throughput Screening? The virtue of HTS If a methodology has to be nominated to the Science Hall of Fame for its contributions in the field of Biology and Chemistry and its interfaces, this is with no doubt High Throughput Screening (HTS). The concept is simple: testing large libraries of entities -compounds, biologicals […]
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2022.02.07
Understanding Lipinski’s Rule of 5 and the Role of LogP Value in Drug Design and Development
An important physicochemical property for a drug compound is its Lipophilicity. This single property dictates many aspects of the performance of the drug, such as solubility, absorption from the gut, membrane permeability, distribution via blood by binding to plasma protein, crossing the blood-brain barrier, organ entry, and metabolism/clearance from the body (ADME properties). The partition […]
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2021.07.30
From Discovery to CMC: Outsourcing via integrated partnerships simplifies the externalization journey
The advantages of a robust outsourcing strategy for pharma and biotech has become clear over the last decades. Outsourcing research and development that would have previously been carried out in-house allows capital efficiency by moving fixed costs into variable cost, and also capital elasticity, with the ability to adjust spending by portfolio needs and data. […]
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